During periods of stress, the body releases neurochemicals that cause inflammation, which can cause overall inflammation in the entire body. The bladder is just one organ that’s affected. Certain people are more susceptible to stress-induced inflammation, causing them to experience more extreme bladder-related symptoms. This can lead to irritation and symptoms of frequency, urgency, or even pain or burning. Other symptoms of stress – such as a less-than-healthy diet with excess caffeine and not allowing time for regularly scheduled bathroom breaks – can also lead to urinary build-up in the bladder and even urinary retention.